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KMID : 1036920150200030136
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Annals of Pediatric Endocrinology & Metabolism
2015 Volume.20 No. 3 p.136 ~ p.142
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Metabolic effects of polycystic ovary syndrome in adolescents
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Han Ye-Jin
Kim Hae-Soon
Lee Hye-Jin
Oh Jee-Young
Sung Yeon-Ah
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Abstract
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Purpose
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenic anovulation in women of reproductive age. We investigated the metabolic effects of lean and overweight adolescents with PCOS.
Methods
Anthropometric measurements and biochemical parameters were evaluated in 49 adolescents with PCOS and 40 age- and body mass index (BMI)-matched controls. We further divided both PCOS and control groups into those having BMI within the normal range of less than 85th percentile and those being overweight and obese with a BMI greater than 85th percentile.
Results
Hemoglobin, gamma-glutamyl transferase (r-GT), total cholesterol, low-density lipoprotein-cholesterol and 2-hour postglucose load plasma insulin levels were significantly elevated in the lean PCOS group than in the lean control group. In the overweight/obese PCOS group, hemoglobin and r-GT levels were significantly elevated than in the overweight/obese control group. In the normal weight group, none of the subjects had metabolic syndrome according to the Adult Treatment Panel III criteria, but the incidence of metabolic syndrome in the overweight/obese PCOS group was 8.3% and that in the overweight/obese control group was 6.7%.
Conclusion
PCOS in adolescents causes metabolic abnormalities, underscoring the importance of early diagnosis of PCOS in oligomenorrheic adolescents.
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KEYWORD
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Polycystic ovary syndrome, Metabolic syndrome, Insulin resistance
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